Water → HCID 86736330, 화합물

HRID 1390788노트

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HRID 1390788 반응식
[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:14]([CH2:15][C@@H:16]([OH:28])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2].F[B-](F)(F)F.[CH2:34]([O+](CC)CC)[CH3:35].O>C(Cl)Cl>[C:1]([O:4][C@H:5]1[CH2:10][CH2:9][C@H:8]2[C@H:11]3[C@H:25]([CH2:26][CH2:27][C@:6]12[CH3:7])[C@:19]1([CH2:20][O:21][C:22](=[O:24])[CH3:23])[C:14]([CH2:15][C@@H:16]([O:28][CH2:34][CH3:35])[CH2:17][CH2:18]1)=[CH:13][CH2:12]3)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 2723982Triethyloxonium tetrafluoroborateHCID 70604761HCID 70604761, 화합물

생성물 1

HCID 86736330HCID 86736330, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5-Androstene-3β,17β,19-triol 17,19-diacetate is dissolved in methylenechloride and triethyloxonium fluoroborate added thereto. After stirring for a period of about two hours at room temperature, water is added to the reaction mixture. The methylenechloride layer is dried over magnesium sulfate and concentrated to dryness. The residue is crystallized from an acetone-hexane mixture to yield the desired 3β-ethoxy-5-androstene-17β,19-diol diacetate.

후처리

  1. dry with materialThe methylenechloride layer is dried over magnesium sulfate
  2. concentrationconcentrated to dryness
  3. customThe residue is crystallized from an acetone-hexane mixture

출처 및 근거

ORD 기록
ord-65f4e78653ba4f05b345502968f47227
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04139617

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