3-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazole → 1-[(3-Chloro-4-monochlorodifluoromethoxy-phenyl)-carbamoyl]-3-(4-chlorophenyl)-2-pyrazoline

HRID 1390971노트

반응식

HRID 1390971 반응식
[Cl:1][C:2]1[C:3]([O:12][CH:13]([F:15])[F:14])=[C:4]([N:9]=[C:10]=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH2:27][CH2:26][NH:25][N:24]=2)=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[Cl:1][C:2]1[C:3]([O:12][CH:13]([F:15])[F:14])=[C:4]([NH:9][C:10]([N:25]2[CH2:26][CH2:27][C:23]([C:20]3[CH:21]=[CH:22][C:17]([Cl:16])=[CH:18][CH:19]=3)=[N:24]2)=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 131437003-(4-Chlorophenyl)-4,5-dihydro-1H-pyrazoleHCID 204494953-Chloro-4-monochlorodifluoromethoxy-phenyl isocyanate

생성물 1

HCID 213322341-[(3-Chloro-4-monochlorodifluoromethoxy-phenyl)-carbamoyl]-3-(4-chlorophenyl)-2-pyrazoline수율 39.1%

시약·촉매·용매 1

HCID 1140Toluene용매2회

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온도
80 °C

실험 절차

12.7 g (0.05 mol) of 3-chloro-4-monochlorodifluoromethoxy-phenyl isocyanate in 20 ml of toluene were added, at 60° C., to a solution of 9 g (0.05 mol) of 3-(4-chlorophenyl)-2-pyrazoline in 60 ml of toluene. The batch was stirred for 2 hours at 80° C. On cooling to room temperature, the product precipitated and was filtered off. 8.5 g (39% of theory) of 1-[(3-chloro-4-monochlorodifluoromethoxy-phenyl)-carbamoyl]-3-(4-chlorophenyl)-2-pyrazoline with a melting point of 161° C. were obtained.

후처리

  1. temperatureOn cooling to room temperature
  2. customthe product precipitated
  3. filtrationwas filtered off

출처 및 근거

ORD 기록
ord-6aeaf124f98345139a15bea2fee8b35e
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04140792

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