1-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazine → 1-(3,5-Difluorophenyl)-4-[(4-aminophenyl)methyl-]piperazine

HRID 1391002노트

반응식

HRID 1391002 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([N+:22]([O-])=O)=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1>[Cl-].[Cl-].[Cl-].[Ti+3]>[F:1][C:2]1[CH:3]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

참가 물질

3

반응물 1

HCID 213318601-(3,5-Difluorophenyl)-4-(p-nitrobenzyl)piperazine

생성물 1

HCID 213318231-(3,5-Difluorophenyl)-4-[(4-aminophenyl)methyl-]piperazine

시약·촉매·용매 1

HCID 10313229titanium(III) trichloride촉매

실험 절차

In the manner given in Example 1B, 1-(3,5-difluorophenyl)-4-(p-nitrobenzyl)piperazine is reduced with aqueous titanium trichloride to give 1-(3,5-difluorophenyl)-4-[(4-aminophenyl)methyl-]piperazine.

출처 및 근거

ORD 기록
ord-49ac441be5be4f849e097f0794f967c8
출처 데이터셋
uspto-grants-1979_02
특허 번호
US04140775

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