Thionyl Chloride → 2-Chloro-1-methyl-5-nitro-1H-benzimidazole

HRID 1391544노트

반응식

HRID 1391544 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=2[NH:4][C:3]1=S.O=S(Cl)[Cl:17]>>[Cl:17][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=2[N:4]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 21226931HCID 21226931, 화합물

생성물 1

HCID 108223912-Chloro-1-methyl-5-nitro-1H-benzimidazole

실험 절차

The compound 1-Methyl-5-nitro-1,3-dihydro-benzoimidazole-2-thione (5.8 g, 27.9 mmol) was heated to reflux with SOCl2 (30 ml) overnight. The reaction mixture was cooled to room temperature and poured into 300 ml of ice water and extracted with CH2Cl2. The organic layers was washed with 10% NaHCO3 water solution, brine, dried over Na2SO4 and concentrated to give the title compound as a yellow solid. MS (ESI) m/z=212 [M+H].

후처리

  1. extractionextracted with CH2Cl2
  2. washThe organic layers was washed with 10% NaHCO3 water solution, brine
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-95436be09f304e759035941098a0666d
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338959B2

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