Cyanogen Bromide → 1-methyl-5-nitro-1H-benzimidazol-2-amine

HRID 1391546노트

반응식

HRID 1391546 반응식
[CH3:1][NH:2][C:3]1[C:4]([NH2:12])=[CH:5][C:6]([N+:9]([O-:11])=[O:10])=[CH:7][CH:8]=1.[N:13]#[C:14]Br>CO>[CH3:1][N:2]1[C:3]2[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:4]=2[N:12]=[C:14]1[NH2:13]

참가 물질

4

반응물 2

HCID 10476Cyanogen BromideHCID 34200251-N-methyl-4-nitrobenzene-1,2-diamine

생성물 1

HCID 450786361-methyl-5-nitro-1H-benzimidazol-2-amine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N1-methyl-4-nitro-benzene-1,2-diamine (200 mg, 1.20 mmol) in methanol (12 ml) was added cyanogen bromide (190.1 mg, 1.79 mmol). After stirring at room temperature for 16 h, the methanol was removed in vacuo and the resulting solid was stirred with diethyl ether (40 ml) for 5 minutes. The resulting hydrobromide salt of the title compound was filtered and air-dried.

후처리

  1. customthe methanol was removed in vacuo
  2. stirringthe resulting solid was stirred with diethyl ether (40 ml) for 5 minutes
  3. filtrationThe resulting hydrobromide salt of the title compound was filtered
  4. customair-dried

출처 및 근거

ORD 기록
ord-a44532fd00534422a86455a70c8c0659
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338959B2

반응 노트

불러오는 중…