Triethylamine → HCID 59676256, 화합물

HRID 1391832

반응식

HRID 1391832 반응식
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH2:12][C@@H:11]([CH3:13])[NH:10][CH2:9][C@@H:8]2[CH3:14])=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][C:31]([C:33](Cl)=[O:34])=[CH:30][C:29]=2[CH:36]=1>C(Cl)Cl>[Cl:24][C:25]1[CH:26]=[CH:27][C:28]2[O:32][C:31]([C:33]([N:10]3[CH2:9][C@@H:8]([CH3:14])[N:7]([CH2:6][C:5]4[CH:15]=[CH:16][C:2]([F:1])=[CH:3][CH:4]=4)[CH2:12][C@@H:11]3[CH3:13])=[O:34])=[CH:30][C:29]=2[CH:36]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 12112118(2S,5R)-1-(4-Fluorobenzyl)-2,5-dimethylpiperazineHCID 337407645-Chloro-1-benzofuran-2-carbonyl chloride

생성물 1

HCID 59676256HCID 59676256, 화합물수율 82%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To an ice cold solution of (trans)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine (712 mg, 3.2 mmol) and triethylamine (506 mg, 5 mmol) in CH2Cl2 (5 mL) a solution of the 5-chloro-1-benzofuran-2-carbonyl chloride (4.2 mmol) in CH2Cl2 (2 mL) was dropwise added. The reaction mixture was stirred at room temperature over night and washed with 0.5 M aqueous NaOH. The organic layer was dried, concentrated and submitted to flash column chromatography (CHCl3/MeOH; 1:0→10:1) to yield 1.05 g (82%) of the title compound.

후처리

  1. washwashed with 0.5 M aqueous NaOH
  2. customThe organic layer was dried
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-bf376f6281c3480e9483948f62cd0490
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07339059B2

연결된 노트

불러오는 중…