2-Amino-5-chlorobenzoic acid → HCID 178433409, 화합물

HRID 1391908노트

반응식

HRID 1391908 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.Cl.[C:13](N)(=[NH:15])[CH3:14]>C(OCCO)C>[Cl:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[C:13]([CH3:14])[N:15]=[C:4]2[OH:6]

참가 물질

4

반응물 2

HCID 124762-Amino-5-chlorobenzoic acidHCID 67170Acetamidine monohydrochloride

생성물 1

HCID 178433409HCID 178433409, 화합물수율 38.6%

시약·촉매·용매 1

HCID 8076Glycol monoethyl ether용매

실험 절차

2-Amino-5-chlorobenzoic acid (3.58 g, 20.9 mmol, 1 eq.), acetamidine hydrochloride (2.36 g, 25.1 mmol, 1.2 eq.) and 2-ethoxyethanol (70 mL) were mixed and refluxed for 48 h. The resultant solids were filtered and dried to yield 1.57 g of yellow solid product. MS (ES+)=195/197 (M+H)++.

후처리

  1. temperaturerefluxed for 48 h
  2. filtrationThe resultant solids were filtered
  3. customdried

출처 및 근거

ORD 기록
ord-8b165043bece4ac4ab78cb842a1ef465
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07338947B2

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