Hydroxylamine → HCID 22719701, 화합물

HRID 1392144노트

반응식

HRID 1392144 반응식
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([S:13](/[CH:16]=[CH:17]/[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)(=[O:15])=[O:14])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:24][OH:25]>C1COCC1>[OH:25][NH:24][CH:17]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)[CH2:16][S:13]([N:10]1[CH2:9][CH2:8][N:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)(=[O:15])=[O:14]

참가 물질

4

반응물 2

HCID 787HydroxylamineHCID 877216HCID 877216, 화합물

생성물 1

HCID 22719701HCID 22719701, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-phenyl-4-(trans-b-styrenesulfonyl)piperazine (108 mg) in THF (3 ml) was added hydroxylamine (0.45 ml, 50% aqueous solution). The mixture was stirred at ambient temperature for 18 hours. Solvent was removed in vauo and the residue dissolved in dichloromethane, washed with water, dried (Na2SO4) and evaporated to give the product 1-[2-(hydroxyamino)-2-phenylethanesulfonyl]-4-phenylpiperazine as a foam (120 mg).

후처리

  1. customSolvent was removed in vauo
  2. dissolutionthe residue dissolved in dichloromethane
  3. washwashed with water
  4. dry with materialdried (Na2SO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-9915ea500de64af88845b4326ae0b14e
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07342020B2

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