1-[4-(4-Nitro-phenyl)-butyl]-1H-[1,2,3]triazole → 4-(4-[1,2,3]Triazol-1-yl-butyl)-phenylamine

HRID 1392221노트

반응식

HRID 1392221 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH:18]=[CH:17][N:16]=[N:15]2)=[CH:6][CH:5]=1)([O-])=O>CO.C1COCC1.[Pd]>[N:14]1([CH2:13][CH2:12][CH2:11][CH2:10][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[CH:18]=[CH:17][N:16]=[N:15]1

참가 물질

4

반응물 1

HCID 184535201-[4-(4-Nitro-phenyl)-butyl]-1H-[1,2,3]triazole

생성물 1

HCID 184535324-(4-[1,2,3]Triazol-1-yl-butyl)-phenylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

1-[4-(4-Nitro-phenyl)-butyl]-1H-[1,2,3]triazole (2.89 g, 11.74 mmol) is hydrogenated in a mixture of methanol/THF (1:1, 50 ml) in the presence of palladium on charcoal (10%, 0.5 g) for 5 h. After filtration solvents are removed in vacuo yielding 4-(4-[1,2,3]triazol-1-yl-butyl)-phenylamine as a yellow gum. Yield 2.03 g (80%)

후처리

  1. filtrationAfter filtration solvents
  2. customare removed in vacuo

출처 및 근거

ORD 기록
ord-d91525802730468c915c1d18f2896f27
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07342030B2

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