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m-Chloroperbenzoic acid → HCID 69313017, 화합물

HRID 1392378
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HRID 1392378 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[CH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].ClC1C=CC=C([C:21](OO)=[O:22])C=1>ClCCl>[O:22]=[C:21]1[CH:10]2[CH:11]1[CH2:12][CH2:13][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:9]2
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참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 13094787tert-Butyl 3,6-dihydropyridine-1(2H)-carboxylate

생성물 1

HCID 69313017HCID 69313017, 화합물수율 142.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To the solution of N-tert-butoxycarbonyl-1,2,3,6-tetrahydropyridine (110 g, 0.60 mol) obtained in Step 1 in 300 ml of dichloromethane, was added 3-chloroperbenzoic acid (m-CPBA; 311 g, 1.80 mol). The reaction mixture was stirred overnight at room temperature and filtered to remove benzoic acid produced. The resulting filtrate was washed with a saturated potassium carbonate solution, brine and distilled water. The resulting organic layer was dried and concentrated on magnesium sulfate to give the titled compound (180.6 g).

후처리

  1. filtrationfiltered
  2. customto remove benzoic acid
  3. customproduced
  4. washThe resulting filtrate was washed with a saturated potassium carbonate solution, brine
  5. distillationdistilled water
  6. customThe resulting organic layer was dried
  7. concentrationconcentrated on magnesium sulfate

출처 및 근거

ORD 기록
ord-cd642a4907304a7082f65317d3ec0807
출처 데이터셋
uspto-grants-2008_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07342027B2

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