2-Bromo-1-chloro-4-(trifluoromethyl)benzene → HCID 10435645, 화합물

HRID 1392426

반응식

HRID 1392426 반응식
Cl.[S:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH:4]=[C:3]1[C:11]([NH:13][C:14]1([C:20]([NH:22][CH:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH:24]2[OH:29])=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12].Br[C:31]1[CH:36]=[C:35]([C:37](F)(F)F)[CH:34]=[CH:33][C:32]=1Cl>>[S:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[CH:4]=[C:3]1[C:11]([NH:13][C:14]1([C:20]([NH:22][CH:23]2[CH2:28][CH2:27][N:26]([C:34]3[CH:33]=[CH:32][CH:31]=[CH:36][C:35]=3[CH3:37])[CH2:25][C:24]2=[O:29])=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)=[O:12]

참가 물질

3

반응물 2

HCID 679882-Bromo-1-chloro-4-(trifluoromethyl)benzeneHCID 69311888HCID 69311888, 화합물

생성물 1

HCID 10435645HCID 10435645, 화합물

실험 절차

In accordance with the same procedure as in Example 85, except that 4-[N-[1-[N-(benzothiophen-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride was used instead of 4-[N-[1-[N-(furan-2-ylcarbonyl)amino]cyclohexanecarbonyl]amino]-3-piperidinol hydrochloride and 1-bromo-2-chloro-5-trifluoromethylbenzene was used instead of 1-bromotoluene in Step 1 thereof, 123 mg of the titled compound was prepared.

출처 및 근거

ORD 기록
ord-43044bf08acf424c9e331f502b09db6e
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07342027B2

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