참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Lithium Hydroxide | HCID 3939 | — |
| 반응물 | cis-Methyl 2-(4-bromophenyl)cyclopropanecarboxylate | HCID 69159174 | — |
| 용매 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 생성물 | 2-(4-Bromophenyl)cyclopropanecarboxylic acid | HCID 301541 | — |
반응 단계
To a solution of ester from step 2 in THF-MeOH (4:1, 0.5M) was added LiOH (3 eq, 2M) and the mixture was stirred at 50° C. for 1 h. The organic solvent was evaporated, the aqueous layer was acidified with HCl 1N and the acid extracted with EtOAc (3×). The combined organic extracts were washed with brine, dried and evaporated to afford 2-(4-bromophenyl)cyclopropanecarboxylic acid. Optically active intermediates were obtained by separation on chiral column (Chiral Pak AD) using hexane:EtOH (90:10 with 0.2% TFA)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07342024B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_03 |
|---|
| ORD ID | ord-7d41fceb5be1484ea087a56183bb0df3 |
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| 출처 메모 | uspto-grants-2008_03 |
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