Methanol → Methyl 3-methoxy-2-(methoxymethyl)propanoate

HRID 1392744

반응식

HRID 1392744 반응식
[CH3:1][O-:2].[Na+].Br[CH2:5][C:6](=[CH2:11])[C:7]([O:9][CH3:10])=[O:8].[CH3:12][OH:13]>C(OCC)C>[CH3:1][O:2][CH2:5][CH:6]([CH2:11][O:13][CH3:12])[C:7]([O:9][CH3:10])=[O:8]

참가 물질

5

반응물 3

HCID 887MethanolHCID 5210932-Propenoic acid, 2-(bromomethyl)-, methyl esterHCID 10942334Sodium Methoxide

생성물 1

HCID 22934772Methyl 3-methoxy-2-(methoxymethyl)propanoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Sodium methoxide (1.21 g) was added to a solution of methyl 2-(bromomethyl)acrylate (1.0 ml) in methanol (10 ml), and the mixture was heated under reflux for 26 hours. After cooling, the reaction mixture was diluted with diethyl ether, and precipitate was collected by filtration and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4) to obtain the title compound (726 mg).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 26 hours
  3. temperatureAfter cooling
  4. filtrationwas collected by filtration
  5. concentrationthe filtrate was concentrated under reduced pressure
  6. customThe resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4)

출처 및 근거

ORD 기록
ord-61a4ad58fd024dc1af01e08dffb50109
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07342014B2

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