Ethyl bromoacetate → Glycine, N-(4-chlorophenyl)-, ethyl ester

HRID 1392758

반응식

HRID 1392758 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 78124-ChloroanilineHCID 11430Potassium Carbonate

생성물 1

HCID 302644Glycine, N-(4-chlorophenyl)-, ethyl ester수율 85.6%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
60 °C

실험 절차

4-Chloroaniline (2.0 g) was dissolved in acetonitrile (20 ml), and ethyl bromoacetate (2.1 g) and potassium carbonate (2.2 g) were added to stir the mixture at 60° C. for 2 days. The reaction mixture was filtered through Celite pad, and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1) to obtain the title compound (2.3 g).

후처리

  1. filtrationThe reaction mixture was filtered through Celite pad
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe resultant residue was purified by column chromatography on silica gel (hexane:chloroform=2:1)

출처 및 근거

ORD 기록
ord-ddfb4b074a4041119d5d2fc3840b3ecd
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07342014B2

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