Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Phenol, 4-nitro-2-(trifluoromethyl)-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | 2-Methoxy-1-nitro-3-(trifluoromethyl)benzene | HCID 21935869 | — |
| 용매 | Hydrogen Bromide | HCID 260 | — |
| 생성물 | Phenol, 4-nitro-2-(trifluoromethyl)- | HCID 3014014 | 83% |
반응 단계
A solution of 6-methoxy-5-nitrobenzotrifluoride (24.73 g, 110.7 mmol) in acetic acid (260 ml) and aqueous HBr solution (62%, 130 ml) was heated to reflux for 96 h, cooled, evaporated and taken up in aqueous saturated NaHCO3 solution/Et2O (3×). The organic phases were washed with aqueous 10% NaCl, dried over Na2SO4 and evaporated to yield 19.27 g (83%) of 4-nitro-2-trifluoromethyl-phenol as yellow solid, MS: 207 (M+), MP: 103-104° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07345067B2 |
| 출처 데이터셋 | uspto-grants-2008_03 |
| ORD ID | ord-c89a3a88ec1846418c848a90c9f9293a |
| 출처 메모 | uspto-grants-2008_03 |