2-(3-Methoxy-prop-1-ynyl)-phenoxy-acetic acid ethyl ester → HCID 67072081, 화합물

HRID 1393094노트

반응식

HRID 1393094 반응식
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]#[C:14][CH2:15][O:16][CH3:17])[CH3:2]>CCOC(C)=O.[Pd]>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[CH2:13][CH2:14][CH2:15][O:16][CH3:17])[CH3:2]

참가 물질

4

반응물 1

HCID 670722722-(3-Methoxy-prop-1-ynyl)-phenoxy-acetic acid ethyl ester

생성물 1

HCID 67072081HCID 67072081, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

9.54 g (38.4 mmol) of the above prepared [2-(3-methoxy-prop-1-ynyl)-phenoxy]-acetic acid ethyl ester was hydrogenated at RT in 130 ml of EtOAc over 2.39 g of Pd/C (10%) under 1 atm. of H2-pressure. After 2 h at ambient temperature, the reaction mixture was filtrated over Celite and carefully rinsed with EtOAc. Evaporation of the solvent left finally 9.39 g of the title compound as colorless oil, MS: 252.2 (M)+.

후처리

  1. filtrationthe reaction mixture was filtrated over Celite
  2. washcarefully rinsed with EtOAc
  3. customEvaporation of the solvent
  4. waitleft finally 9.39 g of the title compound as colorless oil, MS

출처 및 근거

ORD 기록
ord-fa55ada25668461384159b2ef9a05ec7
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345067B2

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