Ethanol → HCID 23033856, 화합물

HRID 1393350노트

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HRID 1393350 반응식
Br[C:2]1[S:3][C:4]2[C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.C(O)C>C(OCC)C>[N:14]1([C:2]2[S:3][C:4]3[C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

5

반응물 3

HCID 702EthanolHCID 8082PiperidineHCID 230338792-Bromo-1,3-benzothiazole-7-carboxylic acid

생성물 1

HCID 23033856HCID 23033856, 화합물수율 90%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
72.5 °C

실험 절차

A mixture of ethyl ester of 2-bromobenzothiazole-7-carboxylic acid (572 mg, 2.00 mmol), piperidine (5 ml) and ethanol (1 ml) was stirred at 70-75° C. for 2.5 hrs. Diethyl ether (15 ml) was added to the mixture at room temperature and the precipitates were filtered off and washed with diethyl ether. The filtrate and washings were combined and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform) to give ethyl ester of 2-piperidinobenzothiazole-7-carboxylic acid (526 mg, 90%) as pale orange crystals.

후처리

  1. filtrationthe precipitates were filtered off
  2. washwashed with diethyl ether
  3. distillationthe solvent was distilled off under reduced pressure
  4. customThe residue was purified by column chromatography on silica gel (chloroform)

출처 및 근거

ORD 기록
ord-81da932fa6cc48f284da6c53c1200355
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345068B2

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