Sodium Bicarbonate → HCID 21937990, 화합물

HRID 1393578

반응식

HRID 1393578 반응식
[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([CH3:16])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+]([O-])([O-])=[O:24].[NH4+].[Ce].C(=O)(O)[O-].[Na+]>S(=O)(=O)(O)O>[C:1]1([N:7]2[C:11]3[CH:12]=[C:13]([CH:16]=[O:24])[CH:14]=[CH:15][C:10]=3[N:9]=[C:8]2[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 130950791,2-diphenyl-6-methyl-1H-benzimidazoleHCID 57418452Ammonium cerium-nitrate

생성물 1

HCID 21937990HCID 21937990, 화합물

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
80 °C

실험 절차

1 g of 1,2-diphenyl-6-methyl-1H-benzimidazole was suspended in 31 ml of 40% sulfuric acid and mixed with 13.5 g of cerium ammonium nitrate. It was allowed to stir for 2.5 hours at 80° C., cooled to 20° C., and carefully stirred into saturated aqueous sodium bicarbonate solution. The mixture was extracted three times with ethyl acetate, the combined extracts were washed with saturated aqueous sodium chloride solution, dried on sodium sulfate solution and evaporated to the dry state in a vacuum. The residue was chromatographed on silica gel.

후처리

  1. temperaturecooled to 20° C.
  2. extractionThe mixture was extracted three times with ethyl acetate
  3. washthe combined extracts were washed with saturated aqueous sodium chloride solution
  4. customdried on sodium sulfate solution
  5. customevaporated to the dry state in a vacuum
  6. customThe residue was chromatographed on silica gel

출처 및 근거

ORD 기록
ord-b443764805da4b96a43973fa49926e84
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345075B2

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