Chloroacetyl chloride → (R)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile

HRID 1393638노트

반응식

HRID 1393638 반응식
[NH:1]1[CH2:8][CH2:7][CH2:6][C@@H:2]1[C:3]([NH2:5])=O.[Cl:9][CH2:10][C:11](Cl)=[O:12]>>[Cl:9][CH2:10][C:11]([N:1]1[CH2:8][CH2:7][CH2:6][C@@H:2]1[C:3]#[N:5])=[O:12]

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 447554Prolinamide, D-

생성물 1

HCID 10920982(R)-1-(2-chloroacetyl)pyrrolidine-2-carbonitrile수율 66%

실험 절차

In a similar procedure as employed in the Intermediate Example 1, D-proline amide (3.2 g) was reacted with chloroacetyl chloride (2.5 ml) and then subjected to dehydration reaction to give the title compound (3.2 g, Y.:66%).

후처리

  1. customsubjected to dehydration reaction

출처 및 근거

ORD 기록
ord-97529f24edb74ab6b26e94f4daf428a6
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345180B2

반응 노트

불러오는 중…