Trifluoroacetic acid → 1-Methyl-2,3-dihydro-1H-indole-5-carboxylic acid

HRID 1393672

반응식

HRID 1393672 반응식
C([SiH](CC)CC)C.[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH:11]=[CH:10]1.FC(F)(F)C(O)=O>ClCCl>[CH3:8][N:9]1[C:17]2[C:12](=[CH:13][C:14]([C:18]([OH:20])=[O:19])=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 70156011-Methyl-1H-indole-5-carboxylic acid

생성물 1

HCID 230920021-Methyl-2,3-dihydro-1H-indole-5-carboxylic acid수율 65.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

Dichloromethane (2 ml) and triethylsilane (1 ml) were added to 1-methyl-1H-indole-5-carboxylic acid (100 mg). The mixture was cooled to 0° C., trifluoroacetic acid (1 ml) was added dropwise thereto, and the mixture was warmed to room temperature and stirred for 2 hours. The reaction mixture was concentrated under reduced pressure, and precipitate was collected by filtration. The precipitate was washed with ether and dried under reduced pressure to give the title compound (66 mg, Y.:65%).

후처리

  1. temperaturethe mixture was warmed to room temperature
  2. concentrationThe reaction mixture was concentrated under reduced pressure, and precipitate
  3. filtrationwas collected by filtration
  4. washThe precipitate was washed with ether
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-7ae5d4a85d124e04a59aa672b7dd4228
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345180B2

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