HCID 23092000, 화합물 → 1-acetylindoline-5-carboxylic acid

HRID 1393674노트

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HRID 1393674 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([O:15]CC3C=CC=CC=3)=[O:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13]([OH:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 23092000HCID 23092000, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 52955471-acetylindoline-5-carboxylic acid수율 48%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The benzyl 1-acetyl-1H-indole-5-carboxylate (550 mg) obtained above was suspended in ethanol (9 ml). 10% Palladium on carbon was added thereto, and the mixture was stirred for 16 hours at room temperature in a hydrogen atmosphere. Insoluble matter was removed by filtration, and the filtrate was concentrated under reduced pressure. Precipitated crystals were collected by filtration, washed with ether and dried under reduced pressure to give the title compound (180 mg, Y.:48%).

후처리

  1. customInsoluble matter was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customPrecipitated crystals
  4. filtrationwere collected by filtration
  5. washwashed with ether
  6. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5a12ce0a24374569b20aba7653d7cafe
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07345180B2

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