Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl p-toluenesulfonate → (+/-)-Benzyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl p-toluenesulfonate | HCID 6645 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (+/-)-(5-Chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine | HCID 11436234 | — |
| 생성물 | (+/-)-Benzyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate | HCID 86598555 | 89% |
반응 단계
Treatment of (±)-1-(5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methanamine (0.83 g, 3.07 mmol) with diisopropylethylamine (1.20 g, 9.28 mmol) followed by benzyl chloroformate (0.79 g, 4.60 mmol) generally according to the procedure described for Intermediate 7 provided 1.00 g (89%) of (±)-benzyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate as a white solid. mp 117-119° C.; Anal. calcd. for C21H18ClNO3.0.5H2O: C, 66.93; H, 5.08; N, 3.72. Found: C, 66.81; H, 4.96; N, 3.67.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728155B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-92529086747c42debf7858c6e4eac049 |
| 출처 메모 | uspto-grants-2010_06 |