Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1394104생성일: 2026년 10월 27일
Triethylamine → Ethyl 2-(3,3-dimethylbutyrylamino)-4,5,6,7-tetrahydrobenzthiazol-4-carboxylate
https://huagongshe.com/reaction/1394104
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| 반응물 | Ethyl 2-amino-4,5,6,7-tetrahydrobenzthiazole-4-carboxyate hydrobromide | HCID 87730500 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Ethyl 2-(3,3-dimethylbutyrylamino)-4,5,6,7-tetrahydrobenzthiazol-4-carboxylate | HCID 59681875 | — |
반응 단계
To a solution of ethyl 2-amino-4,5,6,7-tetrahydrobenzthiazole-4-carboxyate hydrobromide (0.92 g, 0.3 mol) in acetonitrile (25 mL) there was added triethylamine (Et3N, 0.41 g, 0.4 mol). Following cooling to 0° C., tert-butylacetyl chloride (0.55 g, 0.4 mol) was slowly added, and the resultant mixture was then stirred overnight at room temperature. Following removal of the solvent and purification by column chromatography, there was obtained ethyl 2-(3,3-dimethylbutyrylamino)-4,5,6,7-tetrahydrobenzthiazol-4-carboxylate in a yield of 185 mg (corresponding to 19% of theory).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07348347B2 |
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| 출처 데이터셋 | uspto-grants-2008_03 |
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| ORD ID | ord-318e770d7ce649978a8738cfab6f72d1 |
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| 출처 메모 | uspto-grants-2008_03 |
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