Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetate → 2'-Chloro[1,1'-biphenyl]-4-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 1-Bromo-2-chlorobenzene | HCID 12754 | — |
| 반응물 | 4-Formylphenylboronic Acid | HCID 591073 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 2'-Chloro[1,1'-biphenyl]-4-carbaldehyde | HCID 1394400 | — |
반응 단계
To a solution of 2-bromochlorobenzene (0.24 mL, 2 mmol) and 4-formylbenzeneboronic acid (0.35 g, 2.2 mmol) in toluene (20 mL) were added 2M aq. sodium carbonate (2.6 mL) followed by (Ph3P)4Pd (0.34 g, 0.3 mmol). The resulting reaction mixture was refluxed for 3 h, cooled and diluted ethyl acetate. The organic phase was washed with water, saturated aq. sodium bicarbonate, brine and dried over sodium sulfate. The filtrate was concentrated in vacuo and the residue obtained was purified by chromatography (hexane:ethyl acetate; 4:1) to yield the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07348348B2 |
| 출처 데이터셋 | uspto-grants-2008_03 |
| ORD ID | ord-c73cff83589e435d93d15875f07dee8c |
| 출처 메모 | uspto-grants-2008_03 |