Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl chloroformate → (+/-)-Methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl chloroformate | HCID 6586 | — |
| 반응물 | Methyl p-toluenesulfonate | HCID 6645 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | (+/-)-(5-Chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine | HCID 11436234 | — |
| 생성물 | (+/-)-Methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate | HCID 86598556 | 93% |
반응 단계
Treatment of (±)-(5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylamine (2.60 g, 9.62 mmol) with diisopropylethylamine (3.73 g, 28.85 mmol) and methyl chloroformate (1.36 g, 9.62 mmol) generally according to the procedure described for Intermediate 7 afforded 2.60 g (93%) of (±)-methyl (5-chloro-2,3-dihydronaphtho[1,2-b]furan-2-yl)methylcarbamate as a white solid. mp 128-130° C.; Anal. calcd. for C15H14ClNO3: C, 61.76; H, 4.84; N, 4.80. Found: C, 61.43; H, 4.87; N, 4.68.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728155B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-89a55ca56b2f4c6cad993fd79d796618 |
| 출처 메모 | uspto-grants-2010_06 |