Sodium Methoxide → 2,4-Dimethoxy-5-nitropyridine

HRID 1394224

반응식

HRID 1394224 반응식
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1.[CH3:13][O-:14].[Na+]>CO>[CH3:13][O:14][C:2]1[CH:7]=[C:6]([O:8][CH3:9])[C:5]([N+:10]([O-:12])=[O:11])=[CH:4][N:3]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 441196732-Chloro-4-methoxy-5-nitropyridine

생성물 1

HCID 513584872,4-Dimethoxy-5-nitropyridine수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of the product of Step 2 (950 mg, 5 mmol), sodium methoxide (695 mg, 12.5 mmol) in methanol (10 ml) was heated at reflux for 2 hours. After cooling the solvent was removed in vacuo and the residue partitioned between ethyl acetate and water. The organic phase was washed with water and brine, dried and evaporated in vacuo to give the title compound (900 mg, 98%). MS (ES+) m/e 185 [M+H]+.

후처리

  1. temperatureat reflux for 2 hours
  2. temperatureAfter cooling the solvent
  3. customwas removed in vacuo
  4. customthe residue partitioned between ethyl acetate and water
  5. washThe organic phase was washed with water and brine
  6. customdried
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-e370cd43028748c99eff0354a3683c90
출처 데이터셋
uspto-grants-2008_03
특허 번호
US07348339B2

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