Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1394986생성일: 2026년 10월 27일
1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid → Tert-butyl 2-(6-phenylpyrimidin-4-yl)pyrrolidine-1-carboxylate
https://huagongshe.com/reaction/1394986
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-[(Tert-butoxy)carbonyl]pyrrolidine-2-carboxylic acid | HCID 268472 | — |
| 반응물 | 4-Chloro-6-phenylpyrimidine | HCID 593429 | — |
| 시약 | Cesium carbonate | HCID 10796 | — |
| 촉매 | 4,4'-Di-tert-butyl-2,2'-bipyridyl | HCID 4249187 | — |
| 촉매 | Dichloronickel;1,2-dimethoxyethane | HCID 15773433 | — |
| 촉매 | HCID 178441129 | HCID 178441129 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Tert-butyl 2-(6-phenylpyrimidin-4-yl)pyrrolidine-1-carboxylate | HCID 118426415 | 65% |
반응 단계
Prior to irradiation, the reaction mixture was degassed by bubbling argon for 20 minutes
출처 및 근거
| DOI | 10.1126/science.1255525 |
|---|
| 출처 데이터셋 | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
| ORD ID | ord-980f59be0fef4944a93d6d926e7c186a |
|---|
| 출처 메모 | Coupling of α-carboxyl sp3-carbons with aryl halides |
|---|
