p-Toluenesulfonic acid → Benzyl [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetate

HRID 1395482

반응식

HRID 1395482 반응식
[CH:1]([CH:14]1[CH2:19][CH2:18][N:17]([C:20](=[O:27])[CH2:21][O:22][CH2:23][C:24]([OH:26])=[O:25])[CH2:16][CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28]1([CH3:38])[CH:33]=[CH:32][C:31](S(O)(=O)=O)=[CH:30][CH:29]=1>C(O)C1C=CC=CC=1>[CH:1]([CH:14]1[CH2:15][CH2:16][N:17]([C:20](=[O:27])[CH2:21][O:22][CH2:23][C:24]([O:26][CH2:38][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:25])[CH2:18][CH2:19]1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 196442Mcn 4308

생성물 1

HCID 54337918Benzyl [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetate

시약·촉매·용매 1

HCID 244Benzyl Alcohol용매

실험 절차

In a similar operation, 3.63 grams (10 millimoles) of [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetic acid, 50 milliliters of benzyl alcohol and 150 milligrams of p-toluenesulfonic acid are mixed together and the resulting mixture heated at reflux temperature for about 6 hours to obtain a product in the reaction mixture. Thereafter, the reaction mixture subjected to reduced pressure to evaporate the alcohol and the residue is dissolved in benzene, the resulting solution washed with bicarbonate solution, dried and the solvent evaporated to obtain a benzyl [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetate product. The molecular weight of benzyl [2-(4-benzhydrylpiperidino)-2-oxoethoxy]acetate is 453.

후처리

  1. temperaturethe resulting mixture heated
  2. temperatureat reflux temperature for about 6 hours
  3. customto obtain a product in the reaction mixture
  4. customto evaporate the alcohol
  5. dissolutionthe residue is dissolved in benzene
  6. washthe resulting solution washed with bicarbonate solution
  7. customdried
  8. customthe solvent evaporated

출처 및 근거

ORD 기록
ord-f2d81979881a46fe8cff0aac2c8f1a3c
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04203991

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