Ethyl 5-phenylbenzofuran-2-carboxylate → 5-Phenyl-2-benzofurancarboxylic acid

HRID 1395678노트

반응식

HRID 1395678 반응식
[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([O:17]CC)=[O:16])=[CH:12][C:11]=3[CH:20]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>[OH-].[K+]>[C:1]1([C:7]2[CH:8]=[CH:9][C:10]3[O:14][C:13]([C:15]([OH:17])=[O:16])=[CH:12][C:11]=3[CH:20]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 1

HCID 20329644Ethyl 5-phenylbenzofuran-2-carboxylate

생성물 1

HCID 129909085-Phenyl-2-benzofurancarboxylic acid

시약·촉매·용매 1

HCID 14797Potassium Hydroxide용매

실험 절차

A mixture of 1.3 g of Compound 1B and 50 ml of 10% alcoholic potassium hydroxide was refluxed for 4 hours. The solvent was evaporated under reduced pressure and the residue was washed with ether and dissolved in water. The basic solution was acidified with dilute hydrochloric acid and extracted with ether. The ether layer was extracted with dilute sodium bicarbonate solution. The aqueous solution was re-acidified with dilute hydrochloric acid and extracted with ether. The ether extract was dried (Na2SO4) and concentrated under reduced pressure. The residue was crystallized from ethanol to give 5-phenyl-2-benzofurancarboxylic acid (1C), as white solid, mp: 220°-221° C.

후처리

  1. temperaturewas refluxed for 4 hours
  2. customThe solvent was evaporated under reduced pressure
  3. washthe residue was washed with ether
  4. dissolutiondissolved in water
  5. extractionextracted with ether
  6. extractionThe ether layer was extracted with dilute sodium bicarbonate solution
  7. extractionextracted with ether
  8. extractionThe ether extract
  9. dry with materialwas dried (Na2SO4)
  10. concentrationconcentrated under reduced pressure
  11. customThe residue was crystallized from ethanol

출처 및 근거

ORD 기록
ord-160d1a7db5d44aff9b3e04e942fc8931
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04205080

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