5-Benzyloxy-2-(2-[4-phenyl-1-piperazinyl]ethylamino)benzamide → Benzamide, 5-ethoxy-2-((2-(4-phenyl-1-piperazinyl)ethyl)amino)-

HRID 1395802노트

반응식

HRID 1395802 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([NH:18][CH2:19][CH2:20][N:21]2[CH2:26][CH2:25][N:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:23][CH2:22]2)=[C:13]([CH:17]=1)[C:14]([NH2:16])=[O:15])[C:2]1C=CC=CC=1>C(O)C.[Pd]>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([NH:18][CH2:19][CH2:20][N:21]2[CH2:22][CH2:23][N:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:25][CH2:26]2)=[C:13]([CH:17]=1)[C:14]([NH2:16])=[O:15])[CH3:2]

참가 물질

4

반응물 1

HCID 203384875-Benzyloxy-2-(2-[4-phenyl-1-piperazinyl]ethylamino)benzamide

생성물 1

HCID 3050166Benzamide, 5-ethoxy-2-((2-(4-phenyl-1-piperazinyl)ethyl)amino)-수율 45.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

5-Benzyloxy-2-(2-[4-phenyl-1-piperazinyl]ethylamino)benzamide (1.8 g) in 35 ml ethanol was hydrogenated using 1 g 5% Pd-C catalyst. The mixture was heated to boiling and filtered. The filtrate was cooled and the solid filtered and washed to give 0.7 g product, m.142-3.

후처리

  1. temperatureThe mixture was heated
  2. filtrationfiltered
  3. temperatureThe filtrate was cooled
  4. filtrationthe solid filtered
  5. washwashed

출처 및 근거

ORD 기록
ord-8087455ddf284065a91d755b454703be
출처 데이터셋
uspto-grants-1980_05
특허 번호
US04205173

반응 노트

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