Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester → 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester | HCID 69448997 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester | HCID 69447499 | 92% |
반응 단계
A mixture of 1-methyl-3-(4-nitro-phenylmethyl)-1H-indole-5-carboxylic acid methyl ester (0.23 g, 0.71 mmol), Pd (10% on carbon, 30 mg) and methanol (5 mL) was stirred under a hydrogen atmosphere (ballon) for 6 hr. The catalyst was removed by filtration and the solvents removed in vacuo to provide of 3-(4-amino-benzyl)-1-methyl-1H-indole-5-carboxylic acid methyl ester (0.19 g, 92% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08900565B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-3d587e8d0fa246bc923a358c19c0439b |
| 출처 메모 | uspto-grants-2014_12 |