Sulfuric Acid → HCID 58575197, 화합물

HRID 1396658노트

반응식

[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][O:13][CH3:14])[CH:3]=1.S(=O)(=O)(O)O.[N+:20]([O-])([O-:22])=[O:21].[K+]>>[F:1][C:2]1[C:11]([N+:20]([O-:22])=[O:21])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH2:12][O:13][CH3:14])[CH:3]=1

참가 물질

반응물 3

HCID 1118Sulfuric Acid

HCID 24434Potassium Nitrate

HCID 21075354HCID 21075354, 화합물

생성물 1

HCID 58575197HCID 58575197, 화합물수율 87.1%

반응 조건

온도: -10 °C

실험 절차

To a mixture of 1.75 g of methyl 4-fluoro-2-(methoxymethyl)benzoate and 8.7 mL of concentrated sulfuric acid was added 964 mg of potassium nitrate over 5 minutes under cooling at −10° C. After stirring at the same temperature for 4 hours and a half, the reaction mixture was added to 300 mL of ice water, followed by stirring. The solid was collected by filtration, washed with water, and dried under reduced pressure to obtain 1.87 g of methyl 4-fluoro-2-(methoxymethyl)-5-nitrobenzoate.

후처리

stirringby stirring
filtrationThe solid was collected by filtration
washwashed with water
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-3a9e0ac0ad8b41f99fa272fcd0846e4b
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08901126B2

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