Potassium Carbonate → HCID 46916618, 화합물

HRID 1396713노트

반응식

HRID 1396713 반응식
[NH2:1][C:2]1[N:3]=[C:4](S(C)(=O)=O)[C:5]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[S:8][C:6]=2[N:7]=1.[C:18]([O-])([O-])=[O:19].[K+].[K+]>O1CCOCC1.CO>[NH2:1][C:2]1[N:3]=[C:4]([O:19][CH3:18])[C:5]2[N:10]=[C:9]([CH:11]3[CH2:13][CH2:12]3)[S:8][C:6]=2[N:7]=1

참가 물질

5

반응물 2

HCID 11430Potassium CarbonateHCID 66759187HCID 66759187, 화합물

생성물 1

HCID 46916618HCID 46916618, 화합물수율 90%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of 5-amino-2-cyclopropyl-7-(methylsulfonyl)thiazolo[5,4-d]pyrimidine (54 mg, 0.2 mmol) and K2CO3 (69 mg, 0.5 mmol) in dioxane (10 ml) and methanol (5 ml) was stirred at room temperature overnight. The reaction mixture was evaporated in vacuo and purified by flash chromatography on silica, the mobile phase being a mixture of methanol and dichloromethane (in a ratio of 1/60), yielding the pure title compound (40 mg, 90%).

후처리

  1. customThe reaction mixture was evaporated in vacuo
  2. custompurified by flash chromatography on silica
  3. additiona mixture of methanol and dichloromethane (in a ratio of 1/60),

출처 및 근거

ORD 기록
ord-f567f83507e04df293083d718f4dd150
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901132B2

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