Water → 1-[(2-Propen-1-yloxy)carbonyl]-3-pyrazolidinecarboxylic acid

HRID 1396914노트

반응식

HRID 1396914 반응식
[N:1]1([C:20]([O:22][CH2:23][CH:24]=[CH2:25])=[O:21])[CH2:5][CH2:4][CH:3]([C:6]([O:8]C(C)(C)C)=[O:7])[N:2]1C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O.O>ClCCl>[CH2:23]([O:22][C:20]([N:1]1[CH2:5][CH2:4][CH:3]([C:6]([OH:8])=[O:7])[NH:2]1)=[O:21])[CH:24]=[CH2:25]

참가 물질

5

반응물 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 867063572,3-Bis(1,1-dimethylethyl) 1-(2-propen-1-yl) 1,2,3-pyrazolidinetricarboxylate

생성물 1

HCID 682879411-[(2-Propen-1-yloxy)carbonyl]-3-pyrazolidinecarboxylic acid수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2,3-Bis(1,1-dimethylethyl) 1-(2-propen-1-yl) 1,2,3-pyrazolidinetricarboxylate (1.2 g, 3.37 mmol) was dissolved in dichloromethane (DCM) (6.63 ml) under N2 at ambient temperature. TFA (15.56 ml, 202 mmol) and water (1.820 ml, 101 mmol) were added in one portion. The reaction was stirred at ambient temperature for 3 days. The solvent was removed under reduced pressure to give crude 1-[(2-propen-1-yloxy)carbonyl]-3-pyrazolidinecarboxylic acid (0.674 g, 3.37 mmol, 100% crude yield). MS (ES+) m/z 201.0 (MH+).

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-a0f779dd189e4988b1cc95625c56a12b
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901119B2

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