Lipoamide → ethyl (3R)-3-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate
반응식
[OH:1][CH:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][CH2:5][O:4][CH2:3]1.C(OC=C)(=O)CCCCC.C1C(CCCCC(N)=O)SSC1>C(OC(C)C)(C)C>[OH:1][C@@H:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][CH2:5][O:4][CH2:3]1참가 물질
5
반응 조건
- 온도
- 35 °C
실험 절차
To a solution (380 mL) of ethyl 3-hydroxy-3,6-dihydro-2H-pyran-4-carboxylate (91.2 g) in diisopropyl ether were added vinyl hexanoate (150 mL) and Lipozyme IM (4.8 g). The reaction mixture was stirred at 35° C. for 24 hr and the insoluble material was filtered off. The obtained filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography (hexane/ethyl acetate=6:1→1:1) to give the title compound (45.9 g, 50%).
후처리
- filtrationthe insoluble material was filtered off
- concentrationThe obtained filtrate was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-0895eaf6cad8426ba6232aa5b156271a
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08901171B2
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