Chloroacetyl chloride → HCID 178454048, 화합물

HRID 1398089노트

반응식

HRID 1398089 반응식
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:4][CH2:3]1.[Cl:16][CH2:17][C:18](Cl)=[O:19]>>[Cl:16][CH2:17][C:18]([NH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:12])([CH3:14])[CH3:13])[CH2:4][CH2:3]1)=[O:19]

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 178419079HCID 178419079, 화합물

생성물 1

HCID 178454048HCID 178454048, 화합물수율 89%

실험 절차

The title compound 604 mg (89%) was obtained in a manner similar to the Manufacturing Example 3 by use of tert-butyl trans-4-aminocyclo-hexylcarbamate and chloroacetyl chloride, instead of the compound obtained in the Manufacturing Example 2 and acetyl chloride, respectively.

출처 및 근거

ORD 기록
ord-612384b8d748454fa5168f51b7883c2c
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901315B2

반응 노트

불러오는 중…