Sulfuric Acid → Methyl 4-fluoro-3-methoxybenzoate

HRID 1398221

반응식

HRID 1398221 반응식
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12].S(=O)(=O)(O)O.[C:18](=O)([O-])O.[Na+]>CO>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:18])=[O:7])=[CH:4][C:3]=1[O:11][CH3:12]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 5984364-Fluoro-3-methoxybenzoic acid

생성물 1

HCID 592847Methyl 4-fluoro-3-methoxybenzoate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 4-fluoro-3-methoxybenzoic acid (2.33 g) and sulfuric acid (0.2 ml) in methanol (20 mL) was heated under reflux for 10 hr, and allowed to cool to room temperature. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate solution, the solvent was evaporated under reduced pressure, and water was added to the residue. The resultant precipitate was collected by filtration to give the title compound (2.31 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 10 hr
  3. customthe solvent was evaporated under reduced pressure, and water
  4. additionwas added to the residue
  5. filtrationThe resultant precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-7cc02de77cb94e489f83db78c63b9514
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901309B2

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