Potassium Fluoride → 2-(5-Fluoropyridin-2-yl)but-3-yn-2-ol

HRID 1398515노트

반응식

HRID 1398515 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:16])([C:10]#[C:11][Si](C)(C)C)[CH3:9])=[N:6][CH:7]=1.[F-].[K+]>CO.C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([OH:16])([C:10]#[CH:11])[CH3:9])=[N:6][CH:7]=1

참가 물질

5

반응물 2

HCID 522689Potassium FluorideHCID 681818642-(5-Fluoropyridin-2-yl)-4-(trimethylsilyl)but-3-yn-2-ol

생성물 1

HCID 831252472-(5-Fluoropyridin-2-yl)but-3-yn-2-ol수율 86.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2-(5-fluoropyridin-2-yl)-4-(trimethylsilyl)but-3-yn-2-ol (1 g, 4.21 mmol) and potassium fluoride (987 mg, 16.99 mmol) in methanol (10 mL) was stirred for 2 hr at 50° C. The resulting solution was diluted with ethyl acetate (20 mL) and the solid material was removed by filtration. The filtrate was concentrated in vacuo to give 600 mg (86%) of the title compound as yellow oil: LC-MS: m/z=+166 (M+H)+.

후처리

  1. customthe solid material was removed by filtration
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-aa0eb5df16264d5db4862e46b8e4ea23
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901313B2

반응 노트

불러오는 중…