Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(benzyloxy)-1-methyl-1H-pyridin-2-one → 1-Methyl-3-hydroxypyridine-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(benzyloxy)-1-methyl-1H-pyridin-2-one | HCID 68181592 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-Methyl-3-hydroxypyridine-2-one | HCID 88026 | — |
반응 단계
A mixture of 3-(benzyloxy)-1-methyl-1H-pyridin-2-one (23 g, 106.85 mmol) and 10% palladium on carbon (2.3 g) in methanol (250 mL) was stirred under 1 atmosphere of hydrogen for 5 hr at room temperature. The catalyst was removed by filtration. The filtrate was concentrated in vacuo to give the title compound (12 g (90%) as a purple solid: 1H NMR (400 MHz, DMSO) delta 8.96 (s, 1H), 7.15-7.13 (m, 1H), 6.70-6.68 (m, 1H), 6.07 (t, J=7.0 Hz, 1H), 3.47 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08901313B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-d3995e6565174daeafa09f81f8fa05c1 |
| 출처 메모 | uspto-grants-2014_12 |