2-Acetyl-5-methylpyrazine → 2-(5-Methylpyrazin-2-yl)but-3-yn-2-ol

반응식

[C:1]([C:3]1([OH:12])[C:7]2=[N:8][CH:9]=[CH:10][CH:11]=[C:6]2C[CH2:4]1)#[CH:2].CC1[N:15]=CC(C(=O)C)=NC=1>>[CH3:11][C:10]1[N:15]=[CH:6][C:7]([C:3]([OH:12])([C:1]#[CH:2])[CH3:4])=[N:8][CH:9]=1

참가 물질

반응물 2

HCID 309152-Acetyl-5-methylpyrazine

HCID 866695787-ethynyl-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol

생성물 1

HCID 866695792-(5-Methylpyrazin-2-yl)but-3-yn-2-ol

실험 절차

The title compound was prepared using the method described for the preparation of 7-ethynyl-5H,6H-cyclopenta[b]pyridin-7-ol, by replacing 5,6-dihydro-7H-cyclopenta[b]pyridin-7-one with 1-(5-methylpyrazin-2-yl)ethanone; 1H NMR (500 MHz, CDCl3) delta 1.65 (3H, s), 2.45 (3H, s), 4.32 (1H, s), 8.22 (1H, s), 8.77 (1H, s); LC-MS: m/z=+162.9 (M+H)+.

출처 및 근거

ORD 기록: ord-81728adb5d6742e1b5279a3f1fcf13d4
출처 데이터셋: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08901313B2

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