HCID 68736178, 화합물 → 4-Methyl-6-pyrrolidin-1-ylpyridin-3-amine
반응식
[CH3:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][N:5]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:3]=1>[Pd].O1CCCC1>[CH3:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[N:5]=[CH:6][C:7]=1[NH2:8]참가 물질
4
실험 절차
A mixture of 4-methyl-5-nitro-2-pyrrolidin-1-ylpyridine (2.08 g, 10.0 mmol) and 10% palladium on carbon (208 mg) in tetrahydrofuran (10 mL) was stirred under hydrogen atmosphere at room temperature for 16 hr. Catalyst was removed by filtration and the filtrate was concentrated in vacuo to give the title compound (1.76 g, 9.89 mmol, 99%), as a purple solid.
후처리
- customCatalyst was removed by filtration
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-5a17b7db1b0e47148e32451c78d2e64c
- 출처 데이터셋
- uspto-grants-2014_12
- 특허 번호
- US08901141B2
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