N,N,6-trimethyl-5-nitropyridin-2-amine → N2,N2,6-trimethylpyridine-2,5-diamine

HRID 1398861노트

반응식

HRID 1398861 반응식
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[C:5]([CH3:12])[N:4]=1>O1CCCC1.[Pd]>[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([CH3:12])[N:4]=1

참가 물질

4

반응물 1

HCID 59613085N,N,6-trimethyl-5-nitropyridin-2-amine

생성물 1

HCID 20748032N2,N2,6-trimethylpyridine-2,5-diamine수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of N,N,6-trimethyl-5-nitropyridin-2-amine (2.73 g, 15.1 mmol) in tetrahydrofuran (50 mL) was added 10% palladium on carbon (50% wet, 273 mg), and the mixture was purged with hydrogen and stirred under balloon pressure hydrogen at room temperature for 14 hr. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give the title compound as a brown solid (2.30 g, 15.1 mmol).

후처리

  1. customthe mixture was purged with hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-0c47b4cebc9044bbaced7217322c58ff
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901141B2

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