Water → HCID 68773584, 화합물

HRID 1398925노트

반응식

HRID 1398925 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH2:8])[C:3]=1[NH:9][CH2:10][CH2:11][C:12]([O:14][CH2:15]C)=[O:13].Cl.[Cl:18][C:19]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:20]=1[CH:26]([OH:31])[C:27](=N)OC.O>C(O)C>[NH2:8][C:4]1[C:3]2[N:9]([CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])[C:27]([CH:26]([C:20]3[CH:21]=[CH:22][C:23]([Cl:25])=[CH:24][C:19]=3[Cl:18])[OH:31])=[N:1][C:2]=2[CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 68736952HCID 68736952, 화합물HCID 68737549HCID 68737549, 화합물

생성물 1

HCID 68773584HCID 68773584, 화합물수율 90.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of ethyl N-(2,6-diaminophenyl)-beta-alaninate (4.11 g, 18.4 mmol) in ethanol (36.8 mL) was added methyl 2-(2,4-dichlorophenyl)-2-hydroxyethanimidoate hydrochloride (5.59 g, 20.7 mmol) at room temperature. After 12 h, the reaction mixture was poured into water (120 mL). The resulting solid was collected by filtration and washed with ethyl acetate to afford the desired product as colorless solid (6.77 g, 16.6 mmol, 90%).

후처리

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ethyl acetate

출처 및 근거

ORD 기록
ord-963231a023bc494f91e4ab01a8c88520
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08901141B2

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