Piperidine-1-carboxamidine → 2-(6-Oxo-4-phenyl-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

HRID 1399730노트

반응식

HRID 1399730 반응식
[N:1]1([C:7](=[NH:9])[NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:10]([CH:18]([CH:24]([CH2:30][CH2:31][CH3:32])[C:25]([O:27]CC)=[O:26])[C:19](OCC)=[O:20])(=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C[O-].[Na+]>CO>[O:20]=[C:19]1[NH:8][C:7]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:9][C:10]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[C:18]1[CH:24]([CH2:30][CH2:31][CH3:32])[C:25]([OH:27])=[O:26]

참가 물질

5

반응물 3

HCID 205051Piperidine-1-carboxamidineHCID 10942334Sodium MethoxideHCID 66955320Diethyl 2-benzoyl-3-propylsuccinate

생성물 1

HCID 1363461692-(6-Oxo-4-phenyl-2-(piperidin-1-yl)-1,6-dihydropyrimidin-5-yl)pentanoic acid

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

To a solution of piperidine-1-carboximidamide (dimer complexated with H2SO4) (0.6 g; 4.71 mmol) and diethyl 2-benzoyl-3-propylsuccinate (1.51 g; 4.71 mmol) in methanol (5 mL) was slowly added a solution of sodium methoxide in methanol (25% w:w) (2.16 mL; 9.43 mmol) and the reaction was heated to reflux for 21 h. The volatiles were removed under reduced pressure and the crude residue was used as such in the next reaction.

후처리

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 21 h
  3. customThe volatiles were removed under reduced pressure
  4. customsuch in the next reaction

출처 및 근거

ORD 기록
ord-0ff40907276142138d4dc7b53ed5a47b
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906906B2

반응 노트

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