1,2,3,4-Tetrahydroisoquinoline → HCID 86729264, 화합물

HRID 1399857노트

반응식

HRID 1399857 반응식
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:9]=[CH:10][CH:11]=1.[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][NH:21]1>CCO>[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][N:21]1[CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:9]=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 86729263HCID 86729263, 화합물

생성물 1

HCID 86729264HCID 86729264, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

To a solution of tert-butyl (3-(oxiran-2-ylmethoxy)phenyl)carbamate 1.5 g, 5.66 mmol) in EtOH (30 mL) was added 1,2,3,4-tetrahydroisoquinoline 0.828 g, 6.23 mmol). The reaction mixture was heated at 100° C. for 4 h. The solvent was then removed by concentration and the residue dissolved in ethyl acetate, washed with water and the separated organic layer dried over sodium sulfate and concentrated to obtain a crude product. This product was used in next step without further purification.

후처리

  1. customThe solvent was then removed by concentration
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washwashed with water
  4. dry with materialthe separated organic layer dried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ec4ed0fa33d0409a84755c282a700a06
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906900B2

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