Hydrogen chloride-ethyl acetate → HCID 14689279, 화합물

HRID 1399858노트

반응식

HRID 1399858 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][CH:12]([OH:29])[CH2:13][O:14][C:15]1[CH:16]=[C:17]([NH:21]C(=O)OC(C)(C)C)[CH:18]=[CH:19][CH:20]=1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[NH2:21][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][CH2:13][CH:12]([OH:29])[CH2:11][N:2]1[CH2:3][CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:1]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 86729264HCID 86729264, 화합물

생성물 1

HCID 14689279HCID 14689279, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To a solution of tert-butyl (3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropoxy)phenyl)carbamate (1.2 g, 3.01 mmol) in ethyl acetate (30 mL) was added HCl/ethyl acetate (20 mL). The reaction mixture was stirred at room temperature for 2 h. and the concentrated with the residue used in the next step without further purification.

후처리

  1. concentrationthe concentrated with the residue
  2. customused in the next step without further purification

출처 및 근거

ORD 기록
ord-923c2e884a084718817db13fef882991
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906900B2

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