Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → methyl (E)-3-(3-aminophenyl)acrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methyl (2E)-3-(3-nitrophenyl)-2-propenoate | HCID 5354136 | — |
| 촉매 | Iron | HCID 23925 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | methyl (E)-3-(3-aminophenyl)acrylate | HCID 12394366 | 57% |
반응 단계
A solution of (E)-methyl 3-(3-nitrophenyl)acrylate (20.14 g, 0.097 mol), Fe (32.5 g, 0.58 mol), concentrated HCl (3.5 ml) in 50% EtOH (100 ml) was refluxed for 2 h. Upon completion, the solution was filtered through Celite and washed with EtOH. The filtrate was concentrated and extracted with dichloromethane. The combined organic phase was dried over MgSO4 and concentrated to afford (E)-methyl 3-(3-aminophenyl)acrylate as a yellow solid (9.73 g, 57%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08906909B2 |
| 출처 데이터셋 | uspto-grants-2014_12 |
| ORD ID | ord-c4c6ac0849a543009493f1c2594735b1 |
| 출처 메모 | uspto-grants-2014_12 |