Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 14006생성일: 2026년 10월 23일
3-Methoxybenzylamine → tert-Butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate
https://huagongshe.com/ko/reaction/14006
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Methoxybenzylamine | HCID 21156 | — |
| 반응물 | tert-Butyl ((S)-2-(3,5-difluorophenyl)-1-((S)-oxiran-2-yl)ethyl)carbamate | HCID 9922319 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | tert-Butyl (1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-methoxybenzyl)amino]propylcarbamate | HCID 11441951 | — |
반응 단계
tert-Butyl (1S)-2-(3,5-difluorophenyl)-1-[(2S)-oxiranyl]ethylcarbamate (V, EXAMPLE 3, 245 mg, 0.82 mmol) is suspended in isopropyl alcohol (6 mL) and 3-methoxybenzylamine (160 microL, 1.22 mmol) is added with stirring at 20-25 degrees C. This mixture is heated to gentle reflux (bath temp 85 degrees C.) under nitrogen for 2 hours, whereupon the resulting mixture is concentrated under reduced pressure to give the title compound. The title compound is purified by flash chromatography (2-5% methanol/methylene chloride; gradient elution) to give purified title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07727997B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-bbfdc8b43690474290f3fa687cb060d6 |
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| 출처 메모 | uspto-grants-2010_06 |
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