Toluene → HCID 59455074, 화합물

HRID 1400610노트

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HRID 1400610 반응식
[Br:1][C:2](Br)=[CH:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1.CC(C)([O-])C.[K+].C1(C)C=CC=CC=1>O>[Br:1][C:2]#[C:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([F:12])[CH:5]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 23665647Potassium tert-butoxideHCID 594550774-(2,2-Dibromovinyl)-2-fluoro-1-methoxybenzene

생성물 1

HCID 59455074HCID 59455074, 화합물수율 81.4%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A mixture of 1-(2,2-dibromo-vinyl)-3-fluoro-4-methoxybenzene (0.5 g, 0.00161 mol), potassium tertbutoxide (0.36 g, 0.00322 mol) and toluene (6 mL) were heated at 80° C. for 4 h. After completion, the reaction mixture was cooled to RT, diluted with water (15 mL), and extracted with EtOAc (3×50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduce pressure to obtain product as a yellow oil (0.3 g, 81%).

후처리

  1. temperatureAfter completion, the reaction mixture was cooled to RT
  2. extractionextracted with EtOAc (3×50 mL)
  3. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-acfbef9632954084bd9d371f62e710b6
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906925B2

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