1-Chloro-4-(2,2-dibromoethenyl)benzene → 1-(Bromoethynyl)-4-chlorobenzene

HRID 1400611노트

반응식

HRID 1400611 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[C:9](Br)[Br:10])=[CH:4][CH:3]=1.CC(C)([O-])C.[K+]>C1(C)C=CC=CC=1.O>[Br:10][C:9]#[C:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1

참가 물질

5

반응물 2

HCID 64229811-Chloro-4-(2,2-dibromoethenyl)benzeneHCID 23665647Potassium tert-butoxide

생성물 1

HCID 6403901-(Bromoethynyl)-4-chlorobenzene수율 78.1%

시약·촉매·용매 2

HCID 962Water용매HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

To a solution of 1-chloro-4-(2,2-dibromovinyl)benzene (9.60 g, 32.7 mmol) in toluene was added potassium tertbutoxide (7.35 g, 65.6 mmol) at RT. The reaction mixture was heated at 80° C. for 3 h. The reaction was monitored by LCMS and TLC. The reaction mixture was diluted with water and extracted with EtOAc. The organic was dried over sodium sulfate and concentrated under reduced pressure to give the desired product (5.5 g).

후처리

  1. extractionextracted with EtOAc
  2. dry with materialThe organic was dried over sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-af9eeb43a234499e9112352b1f32c4c5
출처 데이터셋
uspto-grants-2014_12
특허 번호
US08906925B2

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